Columbia Study: New Type of Unlabeled GMO Technique May Cause Unpredictable Gene Mutations

 

While the production of genetically engineered crops (also known as GMOs) is currently banned across Europe and in over 30 countries around the world due to health and biodiversity concerns, in the United States they are still quite prevalent.

It’s estimated that over 90 percent of our corn, soy, canola and sugar beets are GMO, most of them engineered to withstand large amounts of Monsanto’s flagship Roundup herbicide, which includes the “probable human carcinogen,” glyphosate.

The process for making these GMOs involves the insertion of DNA from a different species in order to add new characteristics, such as Roundup resistance, to a plant. Prior to their approval the FDA’s own scientists warned the agency about possible unintended consequences and health risks, but they chose to approve the crops anyway.

These GMOs remain unlabeled, a right afforded in over 60 countries.

Now, a major new study is raising concerns about unintended consequences of a new type of genetic modification process — genome editing, which is said to be more specific but actually induces hundreds of unpredictable genome mutations, they say.

Study: CRISPR GMO (Gene Editing) Process May Cause Unintended Mutations

According to a new study from researchers from the Columbia University Medical Center and two other universities, the newest type of genetic modification process mentioned above, using the CRISPR technique aka gene editing, is capable of inducing hundreds of “unintended mutations” into the genome of an organism, in this case mice.

Thus far, CRISPR has been used to create relatively small quantities GMO (aka gene edited in this case) plants such apples, potatoes and mushrooms — the former two are being sold without labels and all are not tested for long term safety.

Gene edited animals are also being developed.

 

Critics are concerned that this new type of GMO, which is created by scientists capable of “tinkering” with our food supply and “turning off” so-called undesired traits in natural foods, could become commonplace while consumers are once again left in the dark about what they may be eating.

According to the study, we may not know the whole picture about this new type of GMO process’s effects on our health after all.

“We feel it’s critical that the scientific community consider the potential hazards of all off-target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,” said co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology & cell biology in the Institute of Genomic Medicine and the Institute of Human Nutrition at Columbia University Medical Center, as quoted in this article from the university.

The study was published in the journal Natural Methods at a time when CRISPR-Cas9 is moving into clinical trials in China. Similar trials are expected in the U.S. next year.

gene editing crispr mutations

Thus far GMO potatoes, mushrooms, and non-browning apples have been created using the CRISPR technique.

 

In the case of this study, an entire genome of mice that had undergone CRISPR gene editing was sequenced, with the goal of looking for all mutations, including those that only altered a single nucleotide, the Columbia article said.

Typically computer algorithms are used to predict possible mutations but in this case they were unable to notice what the researchers found discovered: more than 1,500 single-nucleotide mutations and more than 100 larger deletions and insertions in the genome.

That means that scientists tinkering with genes of different plants and animals may be missing serious side effects that could have harmful long-term consequences for the organisms, and potentially for others who consume them.

“These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off-target effects in living animals,” said co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa according to the Columbia article.

In the study it was found that CRISPR gene editing had successfully corrected a gene that causes blindness, but the many aforementioned collateral mutations were later found.

This article was originally written for March Against Monsanto and was republished with permission. 

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